Tegoprazan-Amoxicillin Dual Therapy

Comparison of 14-Day and 10-Day Regimens vs. Standard Quadruple Therapy

Study Design: Non-inferiority, Multicenter, Randomized Controlled Trial
14-Day Dual Therapy
Tegoprazan + Amoxicillin
TPZ 50mg
AMO 1g
14 Days
Simple regimen: twice daily (BID).
Lower pill burden, high efficacy.
EFFECTIVE (NON-INFERIOR)
90.3%
Eradication Rate (PP)
Recommended as a first-line treatment alternative.
B-Quadruple Therapy
Standard of Care
PPI
Bis
AMO
Tet
14 Days
Complex dosing schedule.
High burden (4 different drugs).
GOLD STANDARD
91.8%
Eradication Rate (PP)
High efficacy, but higher incidence of adverse events.
10-Day Dual Therapy
Short Course
TPZ 50mg
AMO 1g
10 Days
Course reduced to 10 days.
Insufficient exposure time.
NOT RECOMMENDED
67.2%
Eradication Rate (PP)
Efficacy is unacceptably low (<80%).
Safety Profile & Adverse Events (AEs)

14-Day Dual (TPZ)

15.2%
Lower incidence

10-Day Dual (TPZ)

9.4%
Lowest (due to duration)

Standard Quadruple

20.6%
Highest incidence

*Difference in AEs was not statistically significant (p>0.05), but Dual Therapy shows a favorable safety trend.